Siddharthan Chandran is trained in medicine at Southampton University, subsequently undertaking neurology training at the National Hospital for Neurology and Neurosurgery, London, and Cambridge. He was awarded a PhD in developmental neurobiology in 2000 from the University of Cambridge. His previous appointments have included Consultant Neurologist, University Lecturer and Fellow of Kings College at the University of Cambridge. In 2009, he took up the MacDonald Professor of Neurology at the University of Edinburgh where he is also the Director of the Centre for Clinical Brain Sciences and Edinburgh Neuroscience.
The goal of his research, that combines laboratory and clinical activity, is to develop novel treatments for patients with neurodegenerative disorders in the context of Regenerative Neurology. His work is centred on the role of cellular autonomy in neurodegenerative diseases with a particular focus on macroglia. His group’s experimental systems include in vitro patient specific iPSCs and linked in vivo models of inherited tauopathy and inflammatory demyelinating neurodegenerative disease to study glial-neuronal interaction. He also has extensive experience in experimental medicine and early phase proof-of-concept clinical trials.