Workshops

Stemcell Transplantation Patient Demonstration

Workshop round I

An ex-patient (28) had a stemcell transpantation in january 2015. During this interactive demonstration she will tell her story and ofcourse very willing to answer all questions. Matchis Foundation, which is founded by Prof.dr. Jon van Rood - our guestspeaker on Friday the 17th of March, makes sure that all patients if necessart are able to get a stemcell transplantation as fast as possible from the best possible match.  For a successful stemcell transplantation it is essential that the stemcells of the donor and patient are similar. If a family member of the patient is not a match, Matchis will look for a donor throughout the whole world. During this workshop you will get a better picture of how a stemcell transplantation procedure is done.

Vitality & Ageing

Workshop round I
A.J. Poot, A. Akintola & Y. Drewes

Are you interested in causes and consequences of people growing older? In the interactive lecture "Drivers of biological variation in ageing" you will get a first insight in the biological models of ageing, which explains the different variations in ageing. After that there will be an interactive working group "Consequences of biological variation in ageing". Together with your co-participants you will demonstrate that vitality differs between older people. The workshop ends with a discussion and will give you an impression on the vitaly of elder people.

Vitality & Ageing is an innovative international master at the LUMC connecting biological, individual and societal perspectives on ageing. 

Responsible animal experimentation - the collaborative effort of the investigator and the animal facility

Workshop round I & II
Prof. dr. Jan-Bas Prins, Professor of Laboratory Animal Science, Director of the Central Animal Facility

At the LUMC all animal experimentation as well as the breeding of most often unique genetically altered rodents take place in the Central Animal Facility. Only if the facility and the researchers of the LUMC collaborate maximum protection of the welfare of the animals and the highest quality of science can be achieved. You are introduced to the ‘wicked problem’ of animal experimentation and invited to form your own opinion after a tour of one of the units of the facility.

Technological Innovation in Medicine (TIM)

Workshop round II
Berend van Meer & Omar Hertgers

Technological Innonation in Medicine, also known as TIM, is a collaboration between young professionals from the technical and medical sector. Two completely different worlds, when combined, can lead to creative and innovative solutions for currently existing problems. With TIM we want to promte the implementation of technology in healthcare by combining different disciplines. Translation of the latest technologies into practical applications will involve an intensive cooperation between the two worlds. Out-of-the-box solutions, quality of the healthcare and patients’ safety are of greatest importance.

Achieving such solutions is a fun, creative and challenging process, generally driven by a question or a problem from the daily practice of healthcare professionals. In this workshop you will work together on a case and find out how valuable a multidisciplinary approach can be.

Introduction to performing arts medicine

Workshop round II
Dr. A.B.M. Rietveld

Epidemiology, diagnosis, treatment and prevention of injuries in dancers and musicians. An interactive lecture / workshop, presented by A.B.M. (Boni) Rietveld, orthopaedic surgeon/musician. You are invited to bring your musical instrument or dance shoes.

A.B.M.(Boni) Rietveld studied both medicine and music (trumpet and harp). He is a graduate of the Royal Conservatoire for Music in The Hague (trumpet, B.A. music, 1976) and of the Leiden University Medical Centre (M.D., 1978). 

In 1982–83 he had extensive training in dance-orthopaedics in New York City (U.S.A.), working with William G. Hamilton, M.D., orthopaedic surgeon of the New York City Ballet company.

In 1988 he was appointed orthopaedic surgeon of the Nederlands Dans Theater in The Hague and later of the dance-faculty of the Theatre School (National Ballet Academy) of Amsterdam. 
These activities merged into the Medical Centre for Dancers and Musicians (MCDM), which he established in The Hague Medical Centre (HMC) in 1993, and soon celebrating its 25th anniversary.

On April 1st 2005 he founded the Dutch Performing Arts-Medicine Association (NVDMG).

Rietveld is professionally full time involved in Performing Arts-Medicine, as a clinician and researcher. He teaches at Leiden University Medical Centre (LUMC) and presents regularly, both in the Netherlands and abroad, about Performing Arts-Medicine. He is author of the chapter on orthopaedic dance- and musicians-medicine in the Dutch Handbook of Orthopaedics. He has published in several medical scientific and popular magazines. Currently he is working on his PhD-thesis: “Orthopaedic causes of limited and painful relevé in dancers”.

For his ‘tireless efforts to improve healthcare for dancers and musicians, both nationally in The Netherlands and internationally’, he received in 2015 a high royal order of knighthood, ‘Officer in de Orde van Oranje Nassau’.

Exonskipping

Workshop round I
Dr. A.M. Aartsma-Rus

Antisense-mediated exon skipping is a promising therapeutic approach that is currently tested in clinical trials for Duchenne muscular dystrophy. This disease is caused by mutations in the dystrophin gene that disrupt the open reading frame, leading to prematurely truncated, non functional dystrophin proteins. By contrast, patients with mutations in the same gene that maintain the reading frame lead to internally deleted, but partially functional proteins. The aim of the exon skipping approach is to modulate pre-mRNA splicing. Using an antisense oligonucleotide, a chemically modified DNA or RNA homologue, an exon is blocked from the splicing machinery and “skipped” from the mRNA. For Duchenne, exon skipping restores the genetic code, allowing the production of a Becker-like dystrophin instead of a non-functional Duchenne-like dystrophin. In addition to Duchenne muscular dystrophy, this approach has potential for other diseases.In this workshop the exon skipping approach and how this approach can be utilized for different purposes will be introduced. Then the participants will assess in small groups if and how exon skipping can be employed for a specific disease situation. At the end of the workshop, each group will briefly provide their solution to the group and this will be discussed briefly.

The molecular pathology of bone and soft tissue tumours

Workshop round I
Prof. Dr. J.V.M.G. Bovée

Bone and soft tissue tumours are relatively rare and difficult to classify for pathologists. More than 150 subtypes exist with considerable morphological overlap. Distinction is important as the different subtypes have a different outcome and need different treatment. The pathologist uses immunohistochemistry as well as molecular diagnostics to detect molecular alterations that can be of help in the accurate classification of these tumours. At the molecular level, bone and soft tissue tumours can be roughly divided in tumours with 1) deregulated signaling, 2) transcriptional deregulation, and 3) complex chromosomal alterations. The workshop will demonstrate the use of immunohistochemistry and molecular diagnostics in the diagnosis of bone and soft tissue tumours. In addition, examples will be shown of research projects that aim to identify molecular alterations in these tumors, at understanding the mechanisms by which these mutations lead to tumorigenesis, and at finding a way to interfere with these mechanisms in order to improve treatment options for these patients.

Tour of the Anatomical Museum

Workshop round I & II
S. Wielaard

The anatomical collection of the LUMC has been acquired over the past centuries and even contains some preparations that were attained around 1600 AD. The founder of the museum was Bernhard Siegfried Albinus who lived in the 18th century. He was a German professor who worked at Leiden University and who dedicated his life to the anatomy of the body by making the first atlas of human anatomy and by creating a vast collection, a part of which can be seen in the Albinus cabinet. In that antique, wooden cabinet you’ll find some original preparations of the 18th century.

The wall of fame next to the cabinet is an overview of professors who have been important for the further formation of the wide collection of this Anatomical Museum. Over the past centuries 11000 preparations have been collected and the most diverse and special ones have been selected and placed in this museum.

The exhibition
1. The five display cases on the ground floor have been set up around the theme “Healthy and sick”. Each display unit represents a specific phase of human life: it contains a panel with slides of healthy tissue and racks filled with medical sections of physical abnormalities or defects. The racks or ladders are organised after Underwood’s disease classification (General Systematic Pathology). Each such island has two touch screens containing information on the medical sections and sometimes close-ups of the abnormalities.

2. Based on the theme “The Leiden tradition”, historical medical sections are displayed in the 300-year-old Albinus case. There are also paintings by famous anatomists and panels with information about how the collection came into being.

3. On the first floor of the museum, alongside the display case with changing exhibits, you will find a long wall display showing unique medical sections and models and a skeleton display.

Killing the killer only: A future anticancer therapy?

Workshop round II
Prof. M.H.M. Noteborn

World-wide cancer cells kill many patients each year. Unbalances in cell proliferation, cell cycle regulation and/or cell death are underlying processes of cancer development. Many anticancer treatments fail because they are not accurate in targeting cancer-related processes and cause too high side effects. Several viral and cellular proteins harbor a cancer-selective cell death activity: They kill the killer. During the class, the potentials of these exceptional proteins such as the avian virus-derived protein apoptin for the development of novel anticancer therapies and/or identifying essential processes leading to cancer formation will be discussed. The workshop consists also of an interactive element, where the participants can share with each other their imagination of (unknown) molecular mechanisms leading to processes killing only cancer cells. The best imagination will be awarded.

Zooming in on Cell and Tissue Structure with Electron Microscopy

Workshop round II
Dr. C.R. Jost

Electron microscopy can visualize the architecture and structure of tissue and cells with nm-scale resolution. With automation it is possible to acquire and visualize large digital electron microscopy datasets.  Workshop participants will have the opportunity to examine (hands-on) a 5 day old zebrafish embryo over scales ranging from the full organism to individual cells and subcellular structures such as mitochondria, ribosomes and desmosomes (cell-cell connections).

The Allen Brain Atlases: Exploring Transcription Patterns in the Brain

Workshop round II
Dr. A. Mahfouz

To better understand the relationship between genes and brain function, the Allen Institute for Brain Science provides detailed maps of where and when genes are expressed during brain development. This workshop will include: (1) an introduction to the different Allen Brain atlases, (2) examples of research projects incorporating data from the atlases, and (3) a demo of tools to mine the large amount of information available in these atlases.

Zika Virus

Workshop round I
Dr. M.J. Van Hemert and Dr. M.C.W. Feltkamp

Zika virus (ZIKV) is a mosquito-borne virus that has re-emerged in 2015 in Brazil in an unprecedented epidemic form and has since spread to over 60 countries. ZIKV mostly causes asymptomatic infections and when symptomatic mainly causes mild disease characterized by fever, conjunctivitis, skin rash and malaise. However, infections in pregnant women can cause serious birth defects (microcephaly) and in adults in rare cases neurologic complications (Guillain–Barré syndrome). The workshop gives overview of the molecular virological and clinical aspects of ZIKV infection, and includes an interactive activity in which students will work in groups on small assignments related to a ZIKV research response, diagnostics and antivirals.

Tour of the 7-Tesla MRI scanner

Workshop round I
Dr. J.W.M. Beenakker

MRI is an important diagnostic tool, as it can noninvasively image different parts of the body. The strong 7-Tesla MRI of the Gorter Center provides many new opportunities, both in terms of diagnostic power as in technical developments. In this workshop we will present some of the frontiers of the research in MRI, followed by a tour through the lab where new MRI-related hardware is designed. The workshop will end with a demo of the 7-Tesla MRI.

Train your laparoscopic skills

Workshop round I
Dr. E.M. Sandberg

This workshop comprises an introduction to the training of laparoscopic skills. Laparoscopic surgery is a relatively new surgical technique. Despite the advantages of laparoscopy over the conventional open surgical approach for patients, it poses specific demands for the surgeon. The surgeon needs to interpret the three-dimensional operation field from a two-dimensional screen and has to use long instruments with limited freedom of motion. Additionally, the instrument manipulation and camera navigation require good hand-eye coordination. For that reason, and because of ethical and financial constraints, various devices have been developed to train laparoscopic skills outside the operating room. In the skills laboratory of the LUMC box trainers have been designed, validated and have shown to be able to train medical students (without prior experience) up till the level of experts. During the workshop you are introduced to the world of surgical simulation and you will get the opportunity to test and train your own skills. The workshop is organized by Evelien Sandberg. Currently, she is working on a thesis on patient safety in minimally invasive gynaecological surgery and soon he will start his residency in Obstetrics and Gynaecology.

Tips and Tricks for successfully publishing your research work in an international journal

Workshop round I & II
P.G.M. De Jong (Editor-in-Chief, IAMSE) and J.K. Hewett (Journal Production, IAMSE)

Based on several brainstorm exercises and actual experiences from the audience, the presenters will provide tips and recommendations.

In publishing scientific work, not only the writing skills of the author are of importance. At least as important is choosing the right strategy in submitting the work to the most appropriate journal. It is also useful to know how the Editorial Office and Editorial Board of a journal handle the manuscripts received. Knowledge of these last two aspects can significantly increase the chances for acceptance of the manuscript. 

The workshop will give the attendees more insight in the editorial processes of a journal and several concrete strategies to increase the chances of acceptance of their work. First an overview of several journals will be presented and the differences in focuses will be discussed. The presenters will showcase the internal procedures of a specific journal to explain the attendees what is happening behind the scenes of a journal. Some general advice will be given in order to make the process of submission as successful as possible. At the end of the workshop the participants will have a better understanding of scientific publishing and the way in how a manuscript should be submitted.

Towards a world without cervical cancer

Workshop round I
J.J. Beltman, MD, Phd, gynaecologist

Eighty percent of cervical cancer patients live in developing countries and often they are young mothers that play a crucial role in their family or society. Their deaths can be devastating for their communities. Prevention is possible if pre-malignant lesions are diagnosed in time with aceto-acid and women are treated preventively with cryotherapy. The Female Cancer Foundation fights for a world without cervical cancer by promoting the See & Treat method, creating awareness among women and their communities, and training the local health workers. All activities are done by working with and building on already existing organizations and infrastructures, to ensure a sustainable solution to the incidence of cervical cancer.

The foundation is working in more than 20 countries. Future goals will be the implementation of HPV vaccination.

Games for Health

Workshop round I
Jurriaan van Rijswijk, founder of the Games for Health Europe Foundation

Playing with transformation to prevent negative innovation

Shaping the future of healthcare requires disruption - a leap to change. Creative construction as innovation principle means putting patients and healthcare professionals in position to become positive change agents. Creative destruction however is disruption like Uber and AirBNB. This kind of negative innovation only focusses on optimisation of a suboptimal system that in the end won’t lead to improvement and positive change. In this presentation Jurriaan van Rijswijk, founder of the Games for Health Europe Foundation explains how play enabled can improves health care and happiness of people with solid scientific research and plenty examples.

The Games for Health Europe Foundation is the largest worldwide networking ecosystem of people, companies and institutes for research, development and implementation of games within the health ecosystem. In 2014 Jurriaan won the ICT Personality of the Year Award. This award is an acknowledgement for a person who stimulate and impactful applies and implements the use of ICT for the benefit of profit and non-profit organizations as well as governmental organisations.

Hands-on introduction into radio-, fluorescence and ultrasound-guided interventions

Workshop round II
Pip Meershoek, Matthias van Oosterom

Navigation technologies (radio-, fluorescence- and ultrasound-guided) are becoming more and more important for local-regional interventions as such to further minimize this type of image-guided surgical procedures. In this workshop you will get hands-on experience with the latest technologies used in modern-day interventions. The participant can explore the use of an intraoperative navigation system combined with a mobile camera for the localization of radioactive hotspots (representing e.g. tumors, sentinel nodes). Moreover, the participant will be able to experience the concept of navigated ultrasound-guided biopsy for precise needle positioning in a liver phantom containing lesions. Finally a fluorescence imaging system will be demonstrated and the participant will be able to experience hands-on how fluorescence-guidance can help excise target lesions. Through the various phantom experiments the participant will get a feel for the available navigational technologies and their clinical potential.

Of man and monkey: the combat against human disease

Workshop round I & II
Dr. Jan Langermans, Animal Science Department, BPRC, The Netherlands

Despite the increase in non-animal models, well-defined animal models are still required to study many fundamental properties of human diseases. These animal models allow more extensive sampling and studies on new prophylactic and therapeutic treatments to provide proof-of-concept before advancing into clinical trials. However, care must be taken that the use of animals for these purposes is only performed when no alternatives are available. 

Within the scientific community, there is little doubt about the significant role that non-human primates play in studies undertaken to answer specific questions in biomedical research. They are necessary in the struggle against a number of serious diseases affecting humans, simply because no alternatives exist.

However, the use of non-human primates also raises various ethical and practical issues and their application in biomedical research is only acceptable if all necessary animal welfare standards are warranted. The role of non-human primates in various fields of biomedical research and the specific aspects regarding their husbandry and housing to warrant the best possible welfare will be discussed.

Tripoli Airplane Crash; how to identify the mutilated victims

Workshop round II
Prof. dr. Maat

On the 12th of May 2010 an Airbus A 330 crashed into the Libyan Desert in the vicinity of the City of Tripoli. Except for one child, all passengers died. After local recovery of the corpses and their separated body parts, the human remains were transported to the ‘Tripoli Medical Centre’ and the ‘Central Hospital’. In the meantime, the Libyan authorities requested specialized forensic assistance by the Dutch Disaster Victim Identification Team of the National Team for Forensic Investigations (DVI / LTFO). Within 48 hours the team left for Libya to start with their task. The so-called postmortem part of the investigations was completed in four weeks time. At the symposium the complexity and the details of the investigation process will be presented step by step